Relationship of cardiovascular risk factors to dementia subtypes

 
   Lead Investigator:    Brittany Dugger
   Institution      :    Arizona
   E-Mail           :    Brittany.Dugger@ucsf.edu
   Proposal ID      :    352


   Publications:


1  Dugger B
   The presence of tau in peripheral tissues across Alzheimer's disease stages
   43070   Grant  Alzheimer's association   AARG-16-441221   , 

   FUNDED



2  Dugger B
   Tau in peripheral tissues of PSP and CBD
   41943   Grant  CurePSP foundation   531-15   , 

   FUNDED



3  Dugger B
   The effects of APOE genotype on APP and A-beta levels in human liver and brain
   41935   Grant  Arizona Department of Health Services (ADHS), Arizona Biomedical Research Commission (ABRC)   ADHS14-082999   , 

   FUNDED



4  Dugger BN, Hentz JG, Adler CH, Sabbagh MN, Shill HA, Jacobson S, Caviness JN, Belden C, Driver-Dunckley E, Davis KJ, Sue LI, Beach TG
   Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers
   Journal Article  J Neuropathol Exp Neurol,73:244-252,2014,PMC4066814

   PUBLISHED



5  Dugger BN, Hentz JG, Adler CH, Sabbagh MN, Shill HA, Jacobson S, Caviness JN, Belden C, Driver-Dunckley E, Davis KJ, Sue LI, Beach TG, Consortium atAPD
   Neuropathological Outcome of Prospectively Followed Normal Elderly Brain Bank Volunteers
   Abstract  Alzheimers Dement,9:P336,2013,

   PUBLISHED



6  Dugger BN, Malek-Ahmadi M,  Monsell S, Kukull W , Woodruff B, Reiman E, Beach TG, Wilson J
   Cardiovascular Risk Factors and Their Interactions Among Clinically Defined Neurodegenerative Diseases
   Abstract  Alzheimers Dement,10:P151-152,2014,

   PUBLISHED



7  Dugger BN, Malek-Ahmadi M,  Monsell SE, Kukull WA , Woodruff BK, Reiman EM, Beach TG, Wilson J
   A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases
   Journal Article  Alzheimer Dis Assoc Disord,30:223-229,2016,PMC4940303

   PUBLISHED





   Proposal Description:
   The increasing prevalence of cardiovascular risk factors such as obesity, hypertension,   hypercholesterolemia and diabetes has become a major national health concern. These risk   factors have a high probability of causing eventual manifest cardiovascular disease including   myocardial infarction and stroke. Additionally, it has become apparent through longitudinal   epidemiological studies these same factors increase the risk for developing dementia. Almost   all of the attention in this relationship has been focused on Alzheimer???s disease (AD) and   vascular dementia (VaD) with little attention paid to the possible influences on other dementia   subtypes such as dementia with Lewy bodies (DLB) and frontotemporal dementias (FTDs).   These and other non-AD conditions are collectively responsible for 35 or more of all cases of   clinical dementia. Furthermore, most epidemiological studies have not had neuropathological   confirmation of studied subjects, so it is not certain whether cardiovascular conditions are   associated with all types of dementia or just AD and VaD. In Aim 1 of this grant we will evaluate   the prevalence of cardiovascular risk factors and conditions amongst the major, clinically-defined   dementia subtypes (AD, VaD, DLB, and FTD) utilizing the National Alzheimer???s Coordinating   Center database. We will also assess if these same cardiovascular associations affect the rate of   dementia progression. In aim 2 of this proposal, we will determine if cardiovascular risk factors   and/or manifest cardiovascular disease are significantly associated with neuropathologically   confirmed dementia subtypes and the specific pathological changes that define each of these,   using data from subjects that have died and been autopsied. Results from this study will provide   us with an understanding of whether the association of certain cardiovascular factors is limited   to AD and VaD or whether the relationship is common to all major forms of dementia. E